Lindsay Rosenwald – His Journey to Biosciences

Paramount Bio Sciences, LLC, a global pharmaceutical development and health care investment company, was founded and managed by Dr. Lindsay A. Rosenwald in 1991. The company facilitates drug development, scientific support and dedicates itself to finding and developing novel therapeutic medicines with large potential. By assessing promising drug candidates worldwide, Paramount has been able to create, nurture, and support more than 40 life sciences companies, academic centers, biotechnology and pharmaceutical firms over the past 19 years, including 20 in the last 48 months. Current Portfolio Companies have over 40 product candidates advancing through clinical trials.

Unique approach to bio tech investment

Business and product development are just two pieces in the Paramount puzzle. An affiliate of Paramount Bio Sciences – Paramount Bio Capital, Inc., is a FINRA registered broker-dealer that, among other activities, raises capital for the Paramount Portfolio Companies. It raised over $1 billion for the Portfolio Companies; several times that amount has been raised for Paramount Companies by other entities. While venture capital and private equity firms tend to be investment-oriented, Paramount’s bias is on the operational side. It establishes companies from the ground up, using its own capital and eventually funds raised from diverse private and institutional investors through Paramount Bio Sciences and other banks and broker-dealers on Wall Street. Surely, Paramount’s experience in finance and business areas helps make the model attractive to potential licensors and chief executive officers.

With Paramount Capital largely handling accounting, financial, market analytical and legal functions, managers of its Portfolio Companies can focus largely on driving drug candidates through the clinic and creating value for shareholders, licensors and the patient community.

Infrastructure and Company Building at Paramount

Paramount includes an extensive support infrastructure with experience in licensing, clinical development, corporate operations, and navigating regulatory pathways. Every new portfolio company at Paramount Bio Sciences is built around intriguing science and commercial potential. The Portfolio Companies are operated by Paramount Capital through a dedicated first-class management at the company level, as well as through business and clinical development and operations specialists working for Paramount in New York. Chelsea Therapeutics, for example, initially was created or founded by Dr. Rosenwald around a novel anti-folate being developed for the treatment of inflammatory conditions that included rheumatoid arthritis (RA) and psoriasis. Chelsea’s compound, CH-1504, has demonstrated superiority in terms of both safety and efficacy over Methotrexate, the current treatment standard for RA, which has been found to elevate liver enzymes in many patients. Paramount Capital licensed this technology from the University of South Alabama and assembled a world-class management team to help optimize its formulation and advance the development of this and other compounds.

Another academic license from Paramount is a portfolio of organic arsenic trioxide compounds licensed from the MD Anderson Cancer Center. This FDA approved compound progressed from IND to NDA in about 30 months and this is the fastest regulatory approval in the FDA history. Trisenox, an inorganic alternative of arsenic trioxide, which can product produces cardiac abnor¬malities at high doses. By contrast with the inorganic version, organic arsenic trioxide does not show evidence of these problems, even when used at doses 20 times higher than Trisenox. To leverage that advantage, Dr. Rosenwald founded Ziopharm Oncology to advance this organic arsenic compound, ZIO-101, to treat cancers, including solid tumors, where mega dosing has proven effective. Ziopharm Oncology, as one of many Paramount’s portfolio companies, subsequently has in-licensed and is developing several other anti-cancer agents.

Another Paramount portfolio company, founded and managed by Lindsay Rosenwald M.D., is Keryx Bio pharmaceuticals. It is developing a compound called Sulonex, which is an oral therapy for diabetic nephropathy. It was licensed from the Alfa Wassermann Group, a privately held pharmaceutical firm in Bologna, Italy. If approved, Sulonex will be marketed to 15 million people diagnosed with Type 2 diabetes as well as the 1 to 2 million patients with Type 1 diabetes.

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A Look At Italy Soccer

Founded in 1898, the Italian Football League, also known as Italy soccer, is the highest football league in the country. Serie A, which began in 1929, is the top division of Italy Soccer and is primarily sponsored by Italian mobile phone company TIM. Prior to the inception of Serie A, Italy soccer was structured into regional groups. The championship title is commonly referred to as Scudetto, which means' small shield 'because the champions' uniforms will feature a small coat of arms during the following season. After more than 100 years of play, Italy soccer is at the height of it's popularity in both the eyes of the fans and in the media. As we know it today, Serie A is the most elite of all divisions in the Italian Football League. Other divisions include Serie B, Serie C1, Serie C2, Serie D and Eccellenza.

With an Italy soccer league consisting of 18, 18 or 20 teams, Serie A requires that each club play all other teams on two occasions, once at their home stadium and once at the home of their opponents. The first half of a traditional Italy soccer season consists of each team competing once against all of the other clubs. The second half of the season will consist of the same competitions in the same order, with the only difference being the location of the games.

When it comes to scoring, an Italy soccer team receives three points for a win, one point for a tie and no points for a loss. When it comes to tallying the points to see which club will be crowned as champion, teams are ranked according to their total points accumulated during the season. If two teams are found to have equal points at the conclusion of a season, those two teams will meet up in a one match playoff. The top four teams in the Serie A of Italy soccer will qualify for the UEFA Champions League.

Like the area itself, Italy soccer is rich in history and in tradition. With so many years of successful play, the competitors have set a number of records. As of September 2006, three players hold the record for most appearances. These include Paolo Maldini, Gianluca Pagliuca and Dino Zoff. The current records held for the oldest player appearance include Marco Ballotta and Dino Zoff. During the 2005-06 season, AS Roma set the record for most consecutive wins with a total of 11 straight victories.

For additional information on Serie A and / or Italy soccer, fans may visit their official website at http://www.lega-calcio.it . Current standings, news, updates, photos, historical profiles and league news is available online and is offered primarily in the Italian language. A professional design with colorful appeal make this a very popular website among Italy soccer fans. Soccer, itself, remains a popular sport throughout the world and is celebrated in many different countries. With legions of fans worldwide, it appears that soccer players will be kicking high for many years to come.

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Kensington and Chelsea on a Budget

Those not that familiar with London are still aware that Kensington and Chelsea are two of the more expensive and glamorous areas of the big city. So, when you are looking for something different and you’re on a fairly tight budget, where do you start?

Of course when staying in the West End, visiting one of the many museums are excellent options for an enjoyable day out. The Science Museum, Natural History Museum and The Victoria and Albert Museum are all located here and you can visit them for free almost any day of the year.

Head a little further out of the city to Chelsea and you will come across the oldest botanical garden in London – the Chelsea Physic Garden. At only £9 for adults and £6 for students and children it offers a little tranquility away from the hustle and bustle of city life.

Golborne Road market, although connected to Portobello Road offers something a bit different, with a mix of stalls offering a variety of international foods and goods. The area is often referred to as Little Morocco due to the many Moroccan restaurants and shops, so there is definitely a bit of an international feel to the area. Markets are held here every day except Sunday.

Kensington Gardens and Palace are an excellent way to spend some time exploring. The Palace is now home to Wills, Kate and little Prince George so you’ll feel a sense of royalty wandering around, and perhaps you’ll even catch a glimpse of the Royal family. The area is beautiful, any time of year, go and soak up some horticulture!

Another area to enjoy the outdoors is Brompton Cemetery. It might sound a little odd to spend time in graveyard, but this is one of the finest and oldest Victorian graveyards in all of Britain. There are over 200,000 stones and it is considered to be one of the ‘Magnificent Seven’ cemeteries.

Lastly, the London Olympia Exhibition Centre is home to a variety of music shows, food fairs, business events and so much more. Every week there is something different to visit and a lot of the events are free or very cheap.

So, if you are looking for a bit of class on your London city break, but can’t quite afford to dine on the Kensington Roof Gardens, there is still plenty to see and do without burning a hole or three in your pocket.

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Glasgow Rangers Football Club

The 1919/20 season heralded the dawn of a new era for Rangers as manager William Wilton and number two William Struth initiated a Glasgow Rangers dominance that was to last until the outbreak of the Second World War in 1939. Though winning this season with 31 wins out of 42 games and scoring 106 goals, it was overshadowed by the subsequent death of manager, William Wilton.

William Wilton

When the Scottish League was formed in 1890, Wilton became its first treasurer as Rangers shared the title with Dumbarton.

The season before he was appointed to his dual-role, Rangers had achieved the first ever 100% league record, winning all 18 games and scoring 79 goals. No team before or since has ever achieved the same, although several teams have gone unbeaten in a league season since, including Arsenal in 2004.

Rangers were to win 8 league titles with Wilton as manager

Sadly,Wilton did not see the full extent of the team’s success. The day after the final match of the season in 1920, he left or the Bank Holiday, which he planned to spend at Gourock, but he died in a boating accident on the first day of his holiday.

Taking over the manager’s job was William Struth, Struth guided Rangers to a further 14 titles before the war. This period was also noteworthy for the attendances. On the 2nd January 1939 a British league record was broken as 118,567 fans turned out to watch Rangers beat Glasgow Celtic in the traditional new year holiday old firm match.

Glasgow Rangers is a great football club with a great history.

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Around the English Premier League – Round 26

The Citizens keep holding on the leadership, but not yet safe from the imminent danger that represents Manchester United; while Arsenal recovers very well from the Champions League's 4-0 defeat.
By Camilla Mancini

For this round all the changes of the standings where left for the lower half clubs, for the top 10 remain in the same positions. The most relevant change is from the relegation zone, from which the Wolves managed to escape one more time and to replace them in the 18th spot left Blackburn. The Rovers had no chance on Saturday against a Manchester City, which made its rival forget how they defeated United in the last visit they made to the city of Manchester. Instead the Citizens took control from the very beginning of the meeting and with the help of its three top scorers blasted whatever hopes the Rovers had. The Red Devils played until the next day and knowing that they had to achieve the triumph to not open up more the gap in between them and City, scored a last-minute goal.

So Manchester City hosted Blackburn and as mentioned before, left them goalless almost repeating the result from their 1st leg fixture, when the Sky Blues smashed the Rovers with a 4-0 that also included a goal from Balotelli. On Saturday it was Mario Balotelli the first one to get in the score sheet at 30 '; for the rest of first half although City controlled the ball couldn't convert another. Seven minutes after the restart Sergio Agüero score the second and within ten minutes from the end Edin Dzeko grabbed a pass from Kolarov and headed into Paul Robinson's goal. Including the three goals from Saturday, Roberto Mancini's leading strikers have given the squad 39 goals in the Premier season, in fact is the only club that has more than one player with 10 or more goals. The victory has left City with 63pts, still followed by United with 2 points less.

Meanwhile Tottenham continues with 53pts and now has the Gunners 3 points closer, with 46pts thanks to the surprising defeat at Emirates Stadium. Arsenal welcomed the Spurs to their London derby with its heavy artillery preparing to riddle them. Although the visitors started very well grabbing a double lead within the first 34 minutes, with an early goal from Louis Saha and a penalty charged by Emmanuel Adebayor, the Gunners just raised in power and started the bombardment.

Five minutes before the break the first goal was headed by Bacary Sagna -his first goal in 10 matches- and just 3 minutes later the 28-year-old captain, Robin Van Persie, even-up the scoreboard with an outstanding strike. At the return from the interval the midfielder Tomas Rosicky scored his first goal of the season; and just like that Arsenal was leading the game. Around ten minutes passed with both clubs looking for their next goal, but the openings were just for the Gunners, specifically just for Theo Walcott, who scored twice. At 65 'Walcott scored the fourth mark with help of his captain and the fifth after just 3 minutes with assistance from Alex Song. As if it wouldn't have been enough the beat-up the Spurs got, they also got Scott Parker sent-off by the referee when he received a second yellow card at the 87 '. The other matches from round 26: Wigan 0-0 Aston Villa; West Brom 4-0 Sunderland; QPR 0-1 Fulham; Newcastle 2-2 Wolves; Chelsea 3-0 Bolton; Norwich 1-2 Man. United; Stoke 2-0 Swansea.

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A Short Biography of Soccer Player – Louis Saha

His complete name is Louis Laurent Saha. He was born on 8 August 1978 in Paris, France. Saha is a soccer player of French who has a playing position in the field as a forward. In the Premier League currently he plays for Everton club and in his countryside he is a member of the national squad of France.

His first appearance with France is in 2004 when his team won 2-0 against Belgium. Louis Saha stood for France team at the 2004 European Football Championships as well as the 2006 FIFA World Cup which his team got to the final.

His career in club level is with Metz, Fulham, Manchester United, and then Everton. In 1996 Louis Saha began his soccer career with Metz youth academy. In two years Saha starts on the senior lineup of Metz and getting into 47 appearances in favor of the club. In 2000 Saha was moved to Fulham for a fee of £2.1million and as long as his stay at the club in amount of 120 appearances he made 63 goals. In 2004 He was moved to Manchester United club with transfer value of £12.8 million. And in his first season he scored 15 goals for them. He was transferred to Everton for an unrevealed cost, making a sign of a two year agreement with this club.

Saha won same honors as long as his career as professional soccer player and some of them are with Fulham (Football League First Division (1): 2000-2001), and with Manchester United (Premier League (2): 2006-2007, 2007- 2008; Football League Cup (1): 2005- 2006; UEFA Champions League (1): 2007- 2008).

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