An Update on Transdermal Melatonin Use, Sleep Challenges and Jet Lag

Ask a frequent flyer about melatonin and you will probably be met with mixed reviews. While the melatonin website offers a long list of contra-indications (1) users still find it useful to a point. It now looks like the less is more dictum of using melatonin will replace the excessive use of the past. Research is now suggesting that low dose melatonin delivered via the skin (2) may better serve those with sleep challenges including jet lagged frequent flyers.

The jet lag problem faced by frequent flyers was never going to be cured by melatonin alone. Flyers looking for a consummate solution should look at all aspects of their frequent flying lifestyle, however a review of the current research suggests melatonin can play a healthy role in the arsenal of tools at the disposal of frequent flyers.

Here is a round-up of what we know about melatonin at the moment. Starting with melatonin suppression (3) , a lack encourages

  • Cancer proliferation
  • Immunity compromise
  • Disordered energy metabolism
  • Compromised reproductive function and
  • Altered eating behaviors

Normal melatonin production encourages

  • Super antioxidant protection throughout the body
  • Immunological modulation
  • Sleep onset and
  • Regulates hormonal function

The buzz surrounding melatonin shifted gears with research suggesting transdermal melatonin application may be of benefit where traditional melatonin use previously failed. Failures of note are oral melatonin's short elimination half-life cycle, which meant while sleep onset could be achieved, maintaining sleep for the duration was not guaranteed. Another challenge was the possibility of overloading the liver with oral melatonin and its metabolites. As disruptive as this is a knock on effect is in how these metabolites interact with other aspects of the endocrine system.

The average person needs 0.03mg of melatonin to fall asleep. The majority of melatonin pills have multiple times that, up to 300 times. Transdermal melatonin avoids the dangers mentioned above and is easy and convenient to use. Where it really shines is in its ability to keep you asleep in a different time zone when you would normally be awake because of the daylight.

Given the mixed results and possible pitfalls of traditional melatonin use, I was skeptical but hopeful of transdermal melatonin's promise. While my first preference is to always pick natural alternatives (like tart cherries in this instance), I can now say I would use transdermal melatonin alongside other healthy tools in my jet lag beating arsenal.

References

(1) Melatonin.com accessed 20th October 2016

(2) Use of transdermal melatonin delivery to improve sleep maintenance during daytime – Aeschbach, D et al. "Use of Transdermal Melatonin Delivery to Improve Sleep Maintenance during Daytime." Clinical pharmacology and therapeutics 86.4 (2009): 378-382. PMC . Web. 25 Oct. 2016.

(3) Melatonin, sleep disturbance and cancer risk – Sleep Med Rev. 2009 Aug; 13 (4): 257-64. doi: 10.1016 / j.smrv.2008.07.007. Epub 2008 Dec 17

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A Short Biography of Soccer Player – Nicolas Anelka

Nicolas Anelka was born on 14 March 1979 in Versailles. He is a French soccer player who has the role in the field as a striker. For the national side of French, he is a regular starter. Carlo Ancelotti portrays Anelka as a fast player with good aerial aptitude, performance, shooting, ball movement.

Currently in club level Nicolas Anelka plays for Chelsea. Anelka developed to eminence as a productive goal-scorer for Arsenal, and has taken part for a lot of the great clubs across Europe.

Some clubs he has ever joined include Paris Saint-Germain in 1996-1997 and 2000-2002, Arsenal in 1997-1999, Real Madrid in 1999-2000, Liverpool in 2002 and Manchester City in 2002-2005. Afterward He has played for Fenerbahçe and then Chelsea.

At international level Nicolas Anelka has participated lots of times and got the win of his initial international honors with France team at Euro 2000. In the following year he won the Confederations Cup with the team. Anelka’s failure to stay at level of club restricted his international appearances; however he came back to the national side for the competition of Euro 2008.

However, Anelka is an outstanding soccer player and he got many honors and award. Some honors with the club include Arsenal (FA Premier League: 1997-98, FA Cup: 1998, FA Charity Shield: 1998), Real Madrid (UEFA Champions League: 2000), Paris Saint-Germain (UEFA Intertoto Cup: 2001), Fenerbahçe (Turkish Premier Super League: 2004-05), and Chelsea (FA Cup: 2009, FA Community Shield: 2009). For French team his honors are UEFA European Football Championship: 2000 and FIFA Confederations Cup: 2001. And some of his individual honors he achieved Premier League Player of the Month (February 1998, November 2008), PFA Team of the Year (1999, 2009), Barclays Golden Boot (2008-09), PFA Young Player of the Year (1999), and FA Cup Top Scorer (2009).

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Premier League Review – Chelsea Stun Manchester United

Chelsea blew the Premier League title race wide open again when they came from a goal behind to beat Manchester United, with ten games of the season remaining. Chelsea still have a mathematical chance of retaining the league title themselves, although they would have to win the majority of their remaining games while relying on other results to go in their favour.

United who started the game on the back of an impressive run of form, had amazingly not beaten Chelsea at Stamford Bridge since 2002. Chelsea however who have their worst run of form for many seasons were a huge fifteen points adrift of United before the start of the game.

The Blues, who left Didier Drogba on the bench in favour of a Fernando Torres and Nicolas Anelka strike partnership, started the game brightly, but the visitors soon found their stride, with crisp passing and fluent football.

Wayne Rooney, who controversially escaped a ban following his clash with Wigan’s James McCarthy at the weekend, was jeered by the home fans every time he touched the ball. It was Rooney, however, that silenced the Chelsea fans after 29 minutes when he sent a long range shot into the Chelsea goal before celebrating in front of the Chelsea fans.

The Reds, who started with their first unchanged team for 165 games, continued to dominate play during the first half and prevented any real threat from the hosts, although a fine save from Edwin Van der Sar from a Frank Lampard free kick, six minutes before half time, should have set alarm bells ringing and reminded United of the nemesis that Chelsea have been over the last few years.

Chelsea’s hero on the night proved to be David Luiz, who’s arrival from Benfica in the January transfer window was somewhat overshadowed by the £50million signing of Fernando Torres. Luiz was impressive throughout the game and it was his unstoppable shot in the 54th minute that levelled the scores and threw the game wide open.

Both managers made positive, attacking substitutions, with Drogba replacing Anelka for the Blues and Dimitar Berbatov and Ryan Giggs coming on for United, which was a record 606th appearance for Giggs at the club where he began his professional career twenty years ago.

Neither side seemed happy with a draw and both teams went in search of a winning goal, the play and tackles were furious at times as both teams seemed to be playing for pride as much as the three points. After Chris Smalling made a clumsy challenge on Zhirkov in the 80th minute, Frank Lampard, whose impressive penalty record has wavered of late, made no mistake this time as he smashed home the spot kick to give Chelsea a 2-1 lead. Zhirkov nearly added a third goal for the Blues moments late but his shot was deflected onto the post.

To compound United’s misery Vidic was sent off during injury time for a second book able offence, which means he will miss the important trip to Liverpool and the dismissal could leave United defensively weak.

The main beneficiaries of this game would appear to be Arsenal who are now just four points behind the leaders and have a game in hand, while Chelsea have consolidated their quest for a top four Premier League finish and entry into next years Champions League.

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